Diamine Oxidase

What is Diamine Oxidase deficiency?

When the body produces insufficient DAO, or the enzyme’s activity is inhibited, individuals may develop diamine oxidase deficiency. This condition hampers the ability to break down histamine, which can cause symptoms such as digestive discomfort, migraines, flushing, and nasal congestion. Factors contributing to DAO deficiency include genetic predisposition, gastrointestinal disorders, and the use of certain medications that block DAO activity.

Foods to avoid and include with histamine intolerance

For those with diamine oxidase deficiency, dietary adjustments can be crucial. High-histamine foods can exacerbate symptoms and should be minimized. These include:

• Aged cheeses and cured meats
• Fermented foods such as sauerkraut, kimchi, and pickles
• Alcohol, particularly red wine and beer
• Certain fruits, including avocados, tomatoes, and bananas

Conversely, some foods can support histamine metabolism or are naturally low in histamine, making them suitable for individuals with a deficiency. These diamine oxidase foods include:

• Fresh meats and poultry: Unprocessed and freshly cooked options are ideal.
• Fresh fruits: Apples, pears, and berries are generally low in histamine.
• Vegetables: Non-fermented options like zucchini, carrots, and leafy greens.
• Legumes and grains: Lentils, rice, and oats can provide low-histamine options.

How to test for histamine intolerance

If you suspect a diamine oxidase deficiency, a diamine oxidase test can provide clarity. These tests measure the enzyme’s activity in the blood, helping to identify whether low DAO levels contribute to your symptoms. In addition to laboratory testing, an elimination diet can help determine whether histamine-rich foods trigger your symptoms. Consulting a healthcare provider is essential for accurate diagnosis and tailored dietary advice. You can start with an online diamine oxidase test like the one below:

Managing Histamine Intolerance

Understanding the role of diamine oxidase dao in histamine metabolism is key to managing symptoms. For those with low DAO levels, a combination of dietary adjustments, DAO supplements, and proactive testing can lead to significant relief. With the right strategies, individuals with histamine intolerance can enjoy a more comfortable and balanced lifestyle.

By addressing histamine imbalances through informed choices and proper testing, you can take control of your health and minimize the discomfort associated with histamine intolerance.

Next steps

You can read more about the topic in our knowledge bank or you can contact one of our dieticians for personalized advice.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.