DAO histamine block

For individuals with histamine intolerance, the term “DAO histamine block” refers to the reduced activity of diamine oxidase (DAO), an enzyme essential for breaking down histamine in the digestive system. When DAO is not functioning optimally, excess histamine can accumulate, leading to symptoms such as headaches, skin rashes, and digestive discomfort.

Understanding DAO histamine blockers
Certain substances act as a “DAO histamine blocker,” hindering the enzyme’s activity and exacerbating histamine-related symptoms. These DAO blockers include alcohol, specific medications, and some foods. For instance, medications that block DAO, such as certain antidepressants, antihistamines, or anti-inflammatory drugs, can interfere with the enzyme’s effectiveness, making histamine breakdown less efficient.

Avoiding DAO blockers
To manage histamine intolerance, it’s vital to avoid or limit substances that act as DAO blockers. Alcohol, especially red wine and beer, is a well-known inhibitor. Similarly, aged or fermented foods, such as cheese and cured meats, can both contain high levels of histamine and impede DAO function. An example of a DAO supplement is DAO Plus.

Supporting DAO activity
For those affected by DAO histamine block, dietary adjustments, and DAO supplements can help.* Supplements work as DAO histamine blockers’ counteragents by providing additional enzyme support to process dietary histamine. These supplements are especially useful before consuming histamine-rich meals.

Next steps

You can read more about the topic in our knowledge bank or you can contact one of our dieticians for personalized advice. If you’re facing symptoms and don’t know where they come from, you can take the intolerance test for more information:

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.