specialist in digestive health since 2008

specialist in digestive health since 2008

Since 2008, we’ve dedicated ourselves to crafting nutritional supplements. Our team of dieticians meticulously develops our products with exceptional care. We prioritize purity, using only essential ingredients in our formulations. This guarantees our supplements are gluten-free, soy-free, and of superior quality, ensuring safety and minimizing unwanted side effects.

Monash University low FODMAP certified™

Monash University low FODMAP certified™

Select products have been proudly Monash University Low FODMAP Certified™

more than 100,000 satisfied customers

more than 100,000 satisfied customers

Since 2008, our mission has been to “help everyone enjoy their food again.” We are proud to have supported over 100,000 customers.

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Scientific background

Bibliography

  1. Small intestinal glucoamylase deficiency and starch malabsorption: A newly recognised alpha-glucosidase deficiency in children, Lebenthal, Emanuel et al, The Journal of Pediatrics, Volume 124, Issue 4, 541 – 546
  2. Aurigchio, S., Ciccimarra, F., Moauro, L. et al. Intraluminal and Mucosal Starch Digestion in Congenital Deficiency of Intestinal Sucrase and Isomaltase Activities. Pediatr Res 6, 832-839 (1972). https://doi.org/10.1203/00006450-197211000-00004
  3. Frissora CL, Rao SSC. Sucrose intolerance in adults with common functional gastrointestinal symptoms. Proc (Bayl Univ Med Cent). 2022 Aug 23;35(6):790-793. doi: 10.1080/08998280.2022.2114070. PMID: 36304608; PMCID: PMC9586574.
  4. Ohlsson B. Theories behind the effect of starch- and sucrose-reduced diets on gastrointestinal symptoms in irritable bowel syndrome (Review). Mol Med Rep 2021 Oct;24(4):732. doi: 10.3892/mmr.2021.12372. Epub 2021 Aug 20. PMID: 34414452; PMCID: PMC8404103.
  5. Roth B, Ohlsson B. A starch- and sucrose-reduced diet may lead to improvement of intestinal and extraintestinal symptoms in more conditions than irritable bowel syndrome and congenital sucrase-isomaltase deficiency. Nutrition. 2024 Jan;117:112254. doi: 10.1016/j.nut.2023.112254. Epub 2023 Oct 8. PMID: 37924624.
  6. PAZUR JH, ANDO T. The action of an amyloglucosidase of Aspergillus niger on starch and malto-oligosaccharides. J Biol Chem. 1959 Aug;234(8):1966-70. PMID: 13672997.
  7. Lin, A. H., Hamaker, B. R., & Nichols, B. L. (2012). Direct starch digestion by Sucrase-Isomaltase and Maltase-Glucoamylase. Journal of Paediatric Gastroenterology and Nutrition, 55(S2). https://doi.org/10.1097/01.mpg.0000421414.95751.be
  8. Lin, A. H., Nichols, B. L., Quezada-Calvillo, R., Avery, S. E., Sim, L., Rose, D. R., Naim, H. Y., & Hamaker, B. R. (2012). Unexpected high digestion rate of cooked starch by the CT-Maltase-Glucoamylase small intestine mucosal BÉTA-Glucosidase subunit. PLoS ONE, 7(5), e35473. https://doi.org/10.1371/journal.pone.0035473
  9. Nichols, B. L., Avery, S. E., Quezada-Calvillo, R., Kilani, S. B., Lin, A. H., Burrin, D. G., Hodges, B. E., Chacko, S. K., Opekun, A. R., Hindawy, M. E., Hamaker, B. R., & Oda, S. (2017). Improved starch digestion of sucrase-deficient shrews treated with oral glucoamylase enzyme supplements. Journal of Pediatric Gastroenterology and Nutrition, 65(2). https://doi.org/10.1097/mpg.0000000000001561
  10. Riaz, M., Rashid, M. H., Sawyer, L., Akhtar, S., Javed, M. R., Nadeem, H., & Wear, M. (2012). Physiochemical properties and kinetics of glucoamylase produced from deoxy-d-glucose resistant mutant of Aspergillus niger for soluble starch hydrolysis. Food Chemistry, 130(1), 24-30. https://doi.org/10.1016/j.foodchem.2011.06.037
  11. Zhang B, Dhital S, Gidley MJ. Synergistic and antagonistic effects of α-Amylase and amyloglucosidase on starch digestion. Biomacromolecules. 2013 Jun 10;14(6):1945-54. doi: 10.1021/bm400332a. Epub 2013 May 22. PMID: 23647443.
  12. Miloski, Katie & Wallace, Kelly & Fenger, Ashley & Schneider, Ellen & Bendinskas, Kestas (2008). Comparison of Biochemical and Chemical Digestion and Detection Methods for Carbohydrates. Am. J. Undergrad. Res. 7. 10.33697/ajur.2008.015.
  13. Robayo-Torres, C. C., Opekun, A. R., Quezada-Calvillo, R., Villa, X., Smith, E., Navarrete, M., Baker, S. S., & Nichols, B. L. (2009). 13C-Breath tests for sucrose digestion in congenital sucrase isomaltase-deficient and sacrosidase-supplemented patients. Journal of Paediatric Gastroenterology and Nutrition, 48(4), 412-418. https://doi.org/10.1097/mpg.0b013e318180cd09
  14. Treem WR, Ahsan N, Sullivan B, Rossi T, Holmes R, Fitzgerald J, Proujansky R, Hyams J. Evaluation of liquid yeast-derived sucrase enzyme replacement in patients with sucrase-isomaltase deficiency. Gastroenterology. 1993 Oct;105(4):1061-8. doi: 10.1016/0016-5085(93)90950-h. PMID: 8405850.
  15. Treem WR, McAdams L, Stanford L, Kastoff G, Justinich C, Hyams J. Sacrosidase therapy for congenital sucrase-isomaltase deficiency. J Pediatr Gastroenterol Nutr. 1999 Feb;28(2):137-42. doi: 10.1097/00005176-199902000-00008. PMID: 9932843.
  16. Pink IJDiarrhoea due to sucrase and isomaltase deficiency.Gut 1967;8:373-376. Online issue publication, October 26, 2017
  17. Storhaug CL, Fosse SK, Fadnes LT. Country, regional, and global estimates for lactose malabsorption in adults: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2017 Oct;2(10):738-746. doi: 10.1016/S2468-1253(17)30154-1. Epub 2017 Jul 7. PMID: 28690131.
  18. Baijal R, Tandon RK. Effect of lactase on symptoms and hydrogen breath levels in lactose intolerance: A crossover placebo-controlled study. JGH Open. 2020 Dec 1;5(1):143-148. doi: 10.1002/jgh3.12463. PMID: 33490624; PMCID: PMC7812489.
  19. Montalto M, Nucera G, Santoro L, Curigliano V, Vastola M, Covino M, Cuoco L, Manna R, Gasbarrini A, Gasbarrini G. Effect of exogenous beta-galactosidase in patients with lactose malabsorption and intolerance: a crossover double-blind placebo-controlled study. Eur J Clin Nutr. 2005 Apr;59(4):489-93. doi: 10.1038/sj.ejcn.1602098. PMID: 15674309.
  20. Kanabar D, Randhawa M, Clayton P. Improvement of symptoms in infant colic following reduction of lactose load with lactase. J Hum Nutr Diet. 2001 Oct;14(5):359-63. doi: 10.1046/j.1365-277x.2001.00304.x. Erratum in: J Hum Nutr Diet. 2007 Oct;20(5):509. PMID: 11906576.
  21. Ahmed M, Billoo AG, Iqbal K, Memon A. Clinical Efficacy Of Lactase Enzyme Supplement In Infant Colic: A Randomised Controlled Trial. J Pak Med Assoc. 2018 Dec;68(12):1744-1747. PMID: 30504935.
  22. C. Pongracz, M. Pfisterer, A. Missbichler, 22 Orally administered xylose isomerase converts fructose to glucose – a promising approach in case of fructose malabsorption, Clinical Nutrition Supplements, Volume 5, Issue 1, 2010, Pages 12-13, ISSN 1744-1161, https://doi.org/10.1016/S1744-1161(10)70022-3. (https://www.sciencedirect.com/science/article/pii/S1744116110700223)
  23. Bhosale SH, Rao MB, Deshpande VV.1996.Molecular and industrial aspects of glucose isomerase. Microbiol Rev60:.https://doi.org/10.1128/mr.60.2.280-300.1996
  24. Di Stefano, M., Miceli, E., Gotti, S. et al. The Effect of Oral α-Galactosidase on Intestinal Gas Production and Gas-Related Symptoms. Dig Dis Sci 52, 78-83 (2007). https://doi.org/10.1007/s10620-006-9296-9
  25. Shepherd, S., & Gibson, P. (2014). The complete Low-FODMAP diet: The revolutionary plan for managing symptoms in IBS, Crohn’s disease, coeliac disease and other digestive disorders. Random House.
  26. Fedewa A, Rao SS. Dietary fructose intolerance, fructan intolerance and FODMAPs.Curr Gastroenterol Rep. 2014 Jan;16(1):370. doi: 10.1007/s11894-013-0370-0. PMID: 24357350; PMCID: PMC3934501.
  27. Böhn L, Törnblom H, Van Oudenhove L, Simrén M, Störsrud S. A randomised double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome patients. Neurogastroenterol Motil. 2021 Jul;33(7):e14094. doi: 10.1111/nmo.14094. Epub 2021 Feb 22. PMID: 33619835.
  28. Ganiats TG, Norcross WA, Halverson AL, Burford PA, Palinkas LA. Does Beano prevent gas? A double-blind crossover study of oral alpha-galactosidase to treat dietary oligosaccharide intolerance. J Fam Pract. 1994 Nov;39(5):441-5. PMID: 7964541.
  29. Di Pierro F, Bertuccioli A, Marini E, Ivaldi L. A pilot trial on subjects with lactose and/or oligosaccharides intolerance treated with a fixed mixture of pure and enteric-coated α- and β-galactosidase. Clin Exp Gastroenterol. 2015 Feb 19;8:95-100. doi: 10.2147/CEG.S79449. PMID: 25733920; PMCID: PMC4340330.
  30. Hillilä, M., Färkkilä, M. A., Sipponen, T., Rajala, J., & Koskenpato, J. (2015). Does oral α-galactosidase relieve irritable bowel symptoms? Scandinavian Journal of Gastroenterology, 51(1), 16-21. https://doi.org/10.3109/00365521.2015.1063156
  31. Di Stefano, M., Miceli, E., Gotti, S. et al. The Effect of Oral α-Galactosidase on Intestinal Gas Production and Gas-Related Symptoms. Dig Dis Sci 52, 78-83 (2007). https://doi.org/10.1007/s10620-006-9296-9
  32. Di Nardo G, Oliva S, Ferrari F, Mallardo S, Barbara G, Cremon C, Aloi M, Cucchiara S. Efficacy and tolerability of Béta-galactosidase in treating gas-related symptoms in children: a randomised, double-blind, placebo controlled trial. BMC Gastroenterol. 2013 Sep 24;13:142. doi: 10.1186/1471-230X-13-142. PMID: 24063420; PMCID: PMC3849317.
  33. Schnedl, W.J., Schenk, M., Lackner, S. et al. Diamine oxidase supplementation improves symptoms in patients with histamine intolerance. Food Sci Biotechnol 28, 1779-1784 (2019). https://doi.org/10.1007/s10068-019-00627-3
  34. Schnedl WJ, Lackner S, Enko D, Schenk M, Holasek SJ, Mangge H. Evaluation of symptoms and symptom combinations in histamine intolerance. Intest Res. 2019 Jul;17(3):427-433. doi: 10.5217/ir.2018.00152. Epub 2019 Mar 7. PMID: 30836736; PMCID: PMC6667364.
  35. Komericki P, Klein G, Reider N, Hawranek T, Strimitzer T, Lang R, Kranzelbinder B, Aberer W. Histamine intolerance: lack of reproducibility of single symptoms by oral provocation with histamine: a randomised, double-blind, placebo-controlled cross-over study. Wien Klin Wochenschr. 2011 Jan;123(1-2):15-20. doi: 10.1007/s00508-010-1506-y. Epub 2010 Dec 20. PMID: 21165702.
  36. Manzotti G, Breda D, Di Gioacchino M, Burastero SE. Serum diamine oxidase activity in patients with histamine intolerance. Int J Immunopathol Pharmacol. 2016 Mar;29(1):105-11. doi: 10.1177/0394632015617170. Epub 2015 Nov 16. PMID: 26574488; PMCID: PMC5806734.
  37. Izquierdo-Casas J, Comas-Basté O, Latorre-Moratalla ML, Lorente-Gascón M, Duelo A, Soler-Singla L, Vidal-Carou MC. Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomised double-blind trial. Clin Nutr. 2019 Feb;38(1):152-158. doi: 10.1016/j.clnu.2018.01.013. Epub 2018 Feb 15. PMID: 29475774.
  38. Kovacova-Hanuskova E, Buday T, Gavliakova S, Plevkova J. Histamine, histamine intoxication and intolerance. Allergol Immunopathol (Madr). 2015 Sep-Oct;43(5):498-506. doi: 10.1016/j.aller.2015.05.001. Epub 2015 Aug 1. PMID: 26242570.
  39. Martner-Hewes PM, Hunt IF, Murphy NJ, Swendseid ME, Settlage RH. Vitamin B-6 nutriture and plasma diamine oxidase activity in pregnant Hispanic teenagers. Am J Clin Nutr. 1986 Dec;44(6):907-13. doi: 10.1093/ajcn/44.6.907. PMID: 3098085.
  40. Johnston CS, Martin LJ, Cai X. Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. J Am Coll Nutr. 1992 Apr;11(2):172-6. PMID: 1578094.
  41. Kehoe CA, Faughnan MS, Gilmore WS, Coulter JS, Howard AN, Strain JJ. Plasma diamine oxidase activity is greater in copper-adequate than copper-marginal or copper-deficient rats. J Nutr. 2000 Jan;130(1):30-3. doi: 10.1093/jn/130.1.30. PMID: 10613762.
  42. Jones, A. A., DiSilvestro, R. A., Coleman, M., & Wagner, T. L. (1997). Copper supplementation of adult men: Effects on blood copper enzyme activities and indicators of cardiovascular disease risk. Metabolism, 46(12), 1380-1383. https://doi.org/10.1016/s0026-0495(97)90135-9
  43. Failla ML. Considerations for determining ‘optimal nutrition’ for copper, zinc, manganese and molybdenum. Proc Nutr Soc. 1999 May;58(2):497-505. doi: 10.1017/s0029665199000646. PMID: 10466195.
  44. Hunt IF, Murphy NJ, Cleaver AE, Faraji B, Swendseid ME, Browdy BL, Coulson AH, Clark VA, Settlage RH, Smith JC Jr. Zinc supplementation during pregnancy in low-income teenagers of Mexican descent: effects on selected blood constituents and on progress and outcome of pregnancy. Am J Clin Nutr. 1985 Nov;42(5):815-28. doi: 10.1093/ajcn/42.5.815. PMID: 4061343.
  45. Mlcek J, Jurikova T, Skrovankova S, Sochor J. Quercetin and Its Anti-Allergic Immune Response. Molecules. 2016 May 12;21(5):623. doi: 10.3390/molecules21050623. PMID: 27187333; PMCID: PMC6273625.
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