Enzymix vs. Enzymedica Digest Gold: A Full Enzyme Comparison

Enzymix and Enzymedica Digest Gold are both broad-spectrum enzyme capsules for everyday digestion, covering protein, fat, carbohydrates and fiber, rather than a single targeted use case. Here’s how they compare.

Written and reviewed by Anouk Martini, registered dietitian

In short

• Enzymix is a 9-enzyme blend for general digestive support; Digest Gold is a 13-enzyme blend covering the same ground plus four extra fiber-specific enzymes (pectinase, xylanase, hemicellulase, beta-glucanase).[1,3]
• Both are taken with meals: Enzymix 1–3 capsules immediately before or with the first bite, up to 15 per day; Digest Gold 1 capsule per meal, more as needed.[1,3]
• Enzymix costs $29.99 for 36 capsules (about $0.83 per capsule, roughly $0.65 per capsule on the 108-count pack); Digest Gold (45 capsules, with ATPro) runs $33.35–$45.90 depending on retailer, about $0.74–$1.02 per capsule.[1,2,3]

What’s the difference between Enzymix and Digest Gold?

Both cover the same nine enzyme types: amylase, protease, lipase, cellulase, invertase, lactase, maltase, glucoamylase and alpha-galactosidase. Digest Gold adds four further enzymes aimed specifically at plant fiber, pectinase, xylanase, hemicellulase and beta-glucanase, alongside an ATPro blend (ATP, magnesium citrate, phytase, CoQ10) for energy support rather than digestion itself.[3]

Enzyme blend: how to compare strength?

Both labels use different unit systems for several enzymes (IU vs. FCC-based units like GalU, ALU, INVU), so exact strength isn’t directly comparable enzyme-for-enzyme, only presence and relative formulation focus.[1,3]

What each ingredient specifically breaks down

• Amylase: one of the main enzymes involved in starch digestion, starting in the mouth.[5]
• Protease: breaks down proteins into peptides and amino acids.[10]
• Lipase: breaks down fats into fatty acids and glycerol.[10]
• Alpha-galactosidase: humans lack this enzyme themselves, so raffinose-family carbohydrates (found in beans, legumes, cabbage) pass undigested into the colon, where they ferment and cause gas.[4]
• Lactase: breaks down lactose (milk sugar, found in dairy like milk, cheese and cream) into glucose and galactose.[6]
• Invertase (sucrase): breaks down sucrose (table sugar) into glucose and fructose.[7]
• Maltase / glucoamylase: breaks down starches (found in rice, wheat and corn) into glucose.[9]
• Cellulase: breaks down cellulose, a fiber found in plant cell walls. No human clinical trials have been found for cellulase at supplement doses; the evidence base is from animal-feed research.

Digest Gold’s four additional enzymes (pectinase, xylanase, hemicellulase, beta-glucanase) target other plant fibers (pectin, xylan/hemicellulose, beta-glucans). No human clinical trials have been found for these either.

Intoleran – Enzymix

Targeted enzyme mixture for broad meals

• 9 – enzyme mixture targeted for the breakdown of proteins, fats, and carbs, no unneccasary ingredients.
• Helps reduce occasional gas, bloating and indigestion*
• Price per capsule: $0,65 – $0,83 (depends on package size)
• Vegan, dairy, gluten, and soy free

Enzymedica – Digest Gold

General enzyme mixture for broad meals

• 14 – enzyme mixture for the breakdown of proteins, fats and carbs.
• Helps reduce occasional gas, bloating and indigestion*
• Price per capsule: $0.74–$1.02 (depends on retailer)
• Vegan, dairy, gluten, and soy free

Format and dosing

Enzymix: 1–3 capsules immediately before or with the first bite of a meal, up to 15 per day. Capsules can be opened and mixed with food or dissolved in water. Active for 30–45 minutes. Suitable from age 2.[1]

Digest Gold: 1 capsule with each meal, more as needed, no stated maximum.[3]

Price per dose

Enzymix: $29.99 for 36 capsules, about $0.83 per capsule; the 108-count pack is about 22% cheaper per capsule, roughly $0.65.[1] Digest Gold: 45-capsule bottles are priced $33.35–$45.90 across US retailers, about $0.74–$1.02 per capsule.[2,3]

Who is each product for?

Enzymix suits people wanting broad, everyday digestive support across mixed meals, rather than a single specific intolerance. Digest Gold suits the same general use case, with a somewhat wider fiber-enzyme range.

Intoleran Reviews

What does Enzymix do?

Enzymix is a blend of nine digestive enzymes that helps break down fats, proteins, and carbs, and helps reduce occasional gas and bloating, supporting digestive comfort across a wide range of meals.* It is vegan, and free of gluten, soy and dairy.[1] See the Enzymix product page for full details.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

If you suspect a food intolerance but are not yet certain, you can contact one of our dietitians for personalized advice. If you’re looking for enzymes to support your situation, you can try our supplement advisor below.

Do your symptoms persist, or are you losing weight without meaning to, or cutting out more and more foods? Talk to your doctor or a dietitian.

Sources

1. Intoleran — Enzymix product page
2. H-E-B — Digest Gold 45-count US retail price
3. Vitalabo — Digest Gold ATPro full ingredient list and units
4. Arunraj et al., 2020, Plant Signaling & Behavior — DOI
5. Santos et al., 2012, Journal of Nutrigenetics and Nutrigenomics — DOI
6. Dorau et al., 2021, Applied Microbiology and Biotechnology — DOI
7. Danialifar et al., 2024, Journal of Pediatric Gastroenterology and Nutrition — DOI
8. Rose et al., 2018, Journal of Pediatric Gastroenterology and Nutrition — DOI
9. Alfaro Cruz et al., 2017, Pancreas — DOI