Fodmix (Quatrase 10.000) vs. Fodzyme: How Do they Compare?

Fodmix and Fodzyme are both digestive enzyme supplements formulated to help break down FODMAPs. Fodmix, from Intoleran, packs four enzymes into a capsule for fructans, galactans, fructose, lactose and sucrose. Fodzyme uses a three-enzyme powder blend you sprinkle on food. The two differ in enzyme spectrum, format, dosing and price, compared below.

Written by and reviewed by Anouk Martini registered dietitian

In short

• Fodmix contains four enzymes (alpha-galactosidase, xylose isomerase, lactase, invertase) (1); Fodzyme’s blend has three (fructan hydrolase, lactase, alpha-galactosidase) and does not include a dedicated fructose or sucrose enzyme (2).
• Fodmix is a capsule taken before or with a meal; Fodzyme is a powder sprinkled on or mixed into food.
• Fodmix costs $49.99 for 36 capsules (about $1.39 per capsule).[1] Fodzyme costs $79.99 either way: the Home Kit gives 60 smaller doses (about $1.33 per dose, or $1.08 subscribed) (2), the On-the-Go Kit gives 30 larger doses with 33% more enzyme activity (about $2.67 per dose).[3]
• Fodmix is Low FODMAP Certified by Monash University and ships with a 100-day satisfaction guarantee.[1] Fodzyme is also Low FODMAP Certified by Monash University, and additionally FODMAP Friendly certified.[2]

What’s the difference between Fodmix and Fodzyme?

The main difference is enzyme coverage and format. Fodmix combines four enzymes in one capsule, covering fructans/galactans, fructose, lactose and sucrose. Fodzyme’s powder blend covers fructans/galactans and lactose, but has no dedicated enzyme for fructose or sucrose. Fodmix is swallowed or opened into water; Fodzyme is sprinkled directly onto food.

Enzyme blend: what each product breaks down

Fodmix declares a specific activity unit per enzyme (u, FCC), the format the industry uses to make potency comparable across products.[5] Fodzyme’s label discloses a combined blend weight only (32 mg per stick pack, or 24 mg per scoop from the jar), without a per-enzyme activity unit or the proportion of each enzyme in that blend.[3,4] That’s a labeling difference, not a claim about which product is stronger, weight (mg) and activity units aren’t the same measurement, so the two can’t be converted into one number for a side-by-side comparison.

What each ingredient specifically breaks down

• Alpha-galactosidase: humans lack this enzyme themselves, so raffinose-family carbohydrates (found in beans, legumes, cabbage) pass undigested into the colon, where they ferment and cause gas.[6]
• Xylose isomerase: helps with the digestion of fructose (found in fruit, honey and some vegetables), creating a 1:1 balance of glucose and fructose so nutrients are more readily absorbed.[7]
• Lactase: breaks down lactose (milk sugar, found in dairy like milk, cheese and cream) into glucose and galactose.[8]
• Invertase (sucrase): breaks down sucrose (table sugar) into glucose and fructose.[9]
• Fructan hydrolase: an inulinase-type enzyme that hydrolyzes fructans and inulin (found in garlic, onions and wheat) into fructose.[10] Fodzyme’s manufacturer has published two studies on its specific fructan hydrolase enzyme: an in vitro test showing 90% of a 3g inulin dose converted to fructose within 30 minutes in a simulated gut model,[11] and a real-world pre-post cohort study in which 78% of 4-week users reported less bloating (P<.01).[12] Both studies were conducted or co-authored by the manufacturer (Kiwi Biosciences); the cohort study also had no control or placebo group.

Format and dosing

Fodmix: capsule, taken 1–3 at a time immediately before or with the first bite of a meal, up to 15 per day. The capsule can be twisted open and the powder mixed with water for those who prefer not to swallow it. Active for 30–45 minutes. Suitable from age 2.[1]

Fodzyme: powder, sprinkled onto or mixed with the problem food, or taken with the first bite. A second dose is recommended if eating continues past 30 minutes, or for a larger meal.[2]

Price per dose

Fodmix: $49.99 for 36 capsules, about $1.39 per capsule.[1] Fodzyme: $79.99 per kit either way, but dose size differs, the Home Kit’s 60 doses work out to about $1.33 per dose ($1.08 subscribed), the On-the-Go Kit’s 30 larger doses (33% more enzyme activity) work out to about $2.67 per dose.[2]

Who is each product for?

Fodmix suits people managing several FODMAP triggers at once, since one capsule covers fructans, galactans, fructose, lactose and sucrose. Fodzyme suits people who prefer not to swallow capsules and mainly react to fructans, galactans or lactose, since it has no dedicated fructose or sucrose enzyme.

Product comparison

Intoleran – Fodmix (Quatrase 10,000)

Broad FODMAP formula

• Broad 4 enzyme blend: Alpha Galactosidase (1200 u), Xylose Isomerase (7500 u), Lactase (10.000 FCC) en Invertase (500 u).
• Price per capsule: $1.15 – $1.39 (depends on package size)
• Vegan, and free of gluten and soy
• Low FODMAP Certified™ by Monash University

Fodzyme

Focused enzyme blend

• 3 enzyme blend: Fructan hydrolase, Alpha Galactosidase and Lactase.
• Price per dose: $1.20 – $2.40 (home vs. travelkit)
• Free of gluten and soy
• Low FODMAP Certified™ by Monash University

What does Fodmix do?

Fodmix (Quatrase 10,000) is a blend of digestive enzymes that helps reduce occasional gas, bloating, and discomfort associated with FODMAP intolerance, allowing meals without a restrictive diet.* It is Low FODMAP Certified™ by Monash University, vegan, and free of gluten and soy.[1] See the Fodmix product page for full details, or browse all FODMAP products.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Fodmix reviews from real customers

If you suspect a food intolerance but are not yet certain you can contact one of our dietitians for personalized advice. If you’re looking for enzymes to support your situation you can try our supplement advisor below!:

Do your symptoms persist, or are you losing weight without meaning to, or cutting out more and more foods? Talk to your doctor or a dietitian.

Sources

1. Intoleran — Fodmix (Quatrase 10,000) product page
2. FODZYME product page, fodzyme.com — pricing, serving sizes, Monash and FODMAP Friendly certification
3. Emerson Ecologics — FODZYME On-the-Go Kit label
4. Fullscript — FODZYME Home Kit label
5. Enzymedica — explanation of FCC activity units vs. weight-based labeling
6. Elango et al., 2022, Frontiers in Plant Science — DOI
7. Benardout et al., 2021, British Journal of Nutrition — DOI
8. Dorau et al., 2021, Applied Microbiology and Biotechnology — DOI
9. Danialifar et al., 2024, Journal of Pediatric Gastroenterology and Nutrition — DOI
10. Raiciu et al., 2026, Molecules — DOI
11. Ochoa et al., 2022, Gastro Hep Advances  — DOI
12. Kaye et al., 2026, Gastro Hep Advances  — DOI