especialista en salud digestiva desde 2008

especialista en salud digestiva desde 2008

Desarrollamos y producimos complementos nutricionales desde 2008. Nuestros productos son especialmente desarrollados con gran cuidado y atención por nuestros dietistas internos. Para la composición de nuestros productos utilizamos únicamente los ingredientes necesarios, por lo que nuestros productos son puros, sin gluten ni soja y de alta calidad. Esto garantiza que nuestros suplementos puedan utilizarse de forma segura y sin efectos secundarios adversos. Nuestros productos son bajos en FODMAP Certified™ por la Universidad de Monash.

asesoramiento dietético gratuito

asesoramiento dietético gratuito

Nuestro equipo de dietistas especializados está siempre a su servicio con consejos prácticos e información adicional sobre nuestros productos. Póngase en contacto con nosotros a través de:

Chat – para un asesoramiento personal rápido y directo
Mail – espana@intoleran.com

más de 100.000 clientes satisfechos

más de 100.000 clientes satisfechos

Desde 2008, nuestra misión es ayudar a todo el mundo a disfrutar de su comida. Estamos orgullosos de atender ya a más de 100.000 clientes.

base científica

bibliografía

  1. Cheng J, Laitila A, Ouwehand AC. Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review. Front Nutr. 2021 Dec 14;8:790561. doi: 10.3389/fnut.2021.790561. PMID: 34970580; PMCID: PMC8712437. 
  1. Ibarra A, Latreille-Barbier M, Donazzolo Y, Pelletier X, Ouwehand AC. Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled, and dose-ranging trial. Gut Microbes. 2018;9(3):236-251. doi: 10.1080/19490976.2017.1412908. Epub 2018 Feb 8. PMID: 29227175; PMCID: PMC6219592. 
  1. Mogna L, Del Piano M, Mogna G. Capability of the two microorganisms Bifidobacterium breve B632 and Bifidobacterium breve BR03 to colonize the intestinal microbiota of children. J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S37-9. doi: 10.1097/MCG.0000000000000234. PMID: 25291125. 
  1. Saggioro A. Probiotics in the treatment of irritable bowel syndrome. J Clin Gastroenterol. 2004 Jul;38(6 Suppl):S104-6. doi: 10.1097/01.mcg.0000129271.98814.e2. Erratum in: J Clin Gastroenterol. 2005 Mar;39(3):261. PMID: 15220671. 
  1. Madempudi, R.S., Ahire, J.J., Neelamraju, J. et al. Randomized clinical trial: the effect of probiotic Bacillus coagulans Unique IS2 vs. placebo on the symptoms management of irritable bowel syndrome in adults. Sci Rep 9, 12210 (2019). https://doi.org/10.1038/s41598-019-48554-x 
  1. Rogha M, Esfahani MZ, Zargarzadeh AH. The efficacy of a synbiotic containing Bacillus Coagulans in treatment of irritable bowel syndrome: a randomized placebo-controlled trial. Gastroenterol Hepatol Bed Bench. 2014 Summer;7(3):156-63. PMID: 25120896; PMCID: PMC4129566. 
  1. Sudha, M. R., Jayanthi, N., Aasin, M., Dhanashri, R.D., & Anirudh, T. (2018). Efficacy of Bacillus coagulans Unique IS2 in treatment of irritable bowel syndrome in children: a double blind, randomised placebo controlled study. Beneficial Microbes, 9(4), 563-572. https://doi.org/10.3920/BM2017.0129 
  1. Bonavina L, Arini A, Ficano L, Iannuzziello D, Pasquale L, Aragona SE, Ciprandi G, On Digestive Disorders ISG. Abincol® (Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, Lactobacillus delbrueckii LDD01), an oral nutraceutical, pragmatic use in patients with chronic intestinal disorders. Acta Biomed. 2019 Jul 10;90(7-S):8-12. doi: 10.23750/abm.v90i7-S.8649. PMID: 31292420; PMCID: PMC6776171. 
  1. Bonavina L, Ariani A, Ficano L, Iannuzziello D, Pasquale L, Aragona SE, Drago L, Ciprandi G, On Digestive Disorders ISG. Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, and Lactobacillus delbrueckii LDD01) in patients undergoing bowel preparation. Acta Biomed. 2019 Jul 10;90(7-S):13-17. doi: 10.23750/abm.v90i7-S.8650. PMID: 31292421; PMCID: PMC6776169. 
  1. Ringel-Kulka T, Palsson OS, Maier D, Carroll I, Galanko JA, Leyer G, Ringel Y. Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study. J Clin Gastroenterol. 2011 Jul;45(6):518-25. doi: 10.1097/MCG.0b013e31820ca4d6. PMID: 21436726; PMCID: PMC4372813. 
  1. Sadrin S, Sennoune SR, Gout B, Marque S, Moreau J, Grillasca J, Pons O, Maixent JM. Lactobacillus acidophilus versus placebo in the symptomatic treatment of irritable bowel syndrome: the LAPIBSS randomized trial. Cell Mol Biol (Noisy-le-grand). 2017 Sep 30;63(9):122-131. doi: 10.14715/cmb/2017.63.9.21. PMID: 28980935. 
  1. Wu KL, Rayner CK, Chuah SK, Changchien CS, Lu SN, Chiu YC, Chiu KW, Lee CM. Effects of ginger on gastric emptying and motility in healthy humans. Eur J Gastroenterol Hepatol. 2008 May;20(5):436-40. doi: 10.1097/MEG.0b013e3282f4b224. PMID: 18403946. 
  1. Karampour, N., Arzi, A., Rezaie, A., Pashmforoosh, M., & Kordi, F. (2019). Gastroprotective Effect of Zingerone on Ethanol-Induced Gastric Ulcers in Rats. Medicina, 55. https://doi.org/10.3390/medicina55030064. 
  1. Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem Toxicol. 2008 Feb;46(2):409-20. doi: 10.1016/j.fct.2007.09.085. Epub 2007 Sep 18. PMID: 17950516. 
  1. Lashgari, N., Roudsari, N., Khayatan, D., Shayan, M., Momtaz, S., Roufogalis, B., Abdolghaffari, A., & Sahebkar, A. (2021). Ginger and its constituents: Role in treatment of inflammatory bowel disease. BioFactors, 48, 21 – 7. https://doi.org/10.1002/biof.1808
  1. Terry R, Posadzki P, Watson LK, Ernst E. The use of ginger (Zingiber officinale) for the treatment of pain: a systematic review of clinical trials. Pain Med. 2011 Dec;12(12):1808-18. doi: 10.1111/j.1526-4637.2011.01261.x. Epub 2011 Nov 4. PMID: 22054010. 
  1. Weerts ZZRM, Masclee AAM, Witteman BJM, Clemens CHM, Winkens B, Brouwers JRBJ, Frijlink HW, Muris JWM, De Wit NJ, Essers BAB, Tack J, Snijkers JTW, Bours AMH, de Ruiter-van der Ploeg AS, Jonkers DMAE, Keszthelyi D. Efficacy and Safety of Peppermint Oil in a Randomized, Double-Blind Trial of Patients With Irritable Bowel Syndrome. Gastroenterology. 2020 Jan;158(1):123-136. doi: 10.1053/j.gastro.2019.08.026. Epub 2019 Aug 27. PMID: 31470006. 
  1. Cappello G, Spezzaferro M, Grossi L, Manzoli L, Marzio L. Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial. Dig Liver Dis. 2007 Jun;39(6):530-6. doi: 10.1016/j.dld.2007.02.006. Epub 2007 Apr 8. PMID: 17420159 
  1. Pittler, M., & Ernst, E. (1998). Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. American Journal of Gastroenterology, 93, 1131-1135. https://doi.org/10.1111/j.1572-0241.1998.00343.x
  1. Weerts, Z., Masclee, A., Witteman, B., Clemens, C., Winkens, B., Brouwers, J., Frijlink, H., Muris, J., Wit, N., Essers, B., Tack, J., Snijkers, J., Bours, A., Ploeg, A., Jonkers, D., & Keszthelyi, D. (2019). Efficacy and Safety of Peppermint Oil in a Randomized Double-blind Trial of Patients With Irritable Bowel Syndrome.. Gastroenterology. https://doi.org/10.1053/j.gastro.2019.08.026
  1. Kline, R., Kline, J., Palma, J., & Barbero, G. (2001). Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children.. The Journal of pediatrics, 138 1, 125-8 . https://doi.org/10.1067/MPD.2001.109606
  1. Platel, K., & Srinivasan, K. (2000). Stimulatory influence of select spices on bile secretion in rats.. Nutrition Research, 20, 1493-1503. https://doi.org/10.1016/S0271-5317(00)80030-5
  1. Kalpana, P., & Srinivasan, K. (2001). A study of the digestive stimulant action of select spices in experimental rats.. Journal of Food Science and Technology-mysore, 38, 358-361. 
  1. Sahoo, S., & Brijesh, S. (2020). Anxiolytic activity of Coriandrum sativum seeds aqueous extract on chronic restraint stressed mice and effect on brain neurotransmitters. Journal of Functional Foods, 68, 103884. https://doi.org/10.1016/j.jff.2020.103884
  1. Jabeen, Q., Bashir, S., Lyoussi, B., & Gilani, A. (2009). Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities.. Journal of ethnopharmacology, 122 1, 123-30 . https://doi.org/10.1016/j.jep.2008.12.016
  1. Heidari, B., Sajjadi, S., & Minaiyan, M. (2016). Effect of Coriandrum sativum hydroalcoholic extract and its essential oil on acetic acid- induced acute colitis in rats. Avicenna Journal of Phytomedicine, 6, 205 – 214. https://doi.org/10.22038/AJP.2016.5157
  1. Achamrah, N., Déchelotte, P., & Coëffier, M. (2017). Glutamine and the regulation of intestinal permeability: from bench to bedside. Current Opinion in Clinical Nutrition and Metabolic Care, 20, 86–91. https://doi.org/10.1097/MCO.0000000000000339. 
  1. Bertrand, J., Ghouzali, I., Guérin, C., Bole-Feysot, C., Gouteux, M., Déchelotte, P., Ducrotte, P., & Coëffier, M. (2016). Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome.. JPEN. Journal of parenteral and enteral nutrition, 40 8, 1170-1176 . https://doi.org/10.1177/0148607115587330
  1. Rastgoo, S., Ebrahimi‐Daryani, N., Agah, S., Karimi, S., Taher, M., Rashidkhani, B., Hejazi, E., Mohseni, F., Ahmadzadeh, M., Sadeghi, A., & Hekmatdoost, A. (2021). Glutamine Supplementation Enhances the Effects of a Low FODMAP Diet in Irritable Bowel Syndrome Management. Frontiers in Nutrition, 8. https://doi.org/10.3389/fnut.2021.746703.  

  1. Giannini EG, Mansi C, Dulbecco P, Savarino V. Role of partially hydrolyzed guar gum in the treatment of irritable bowel syndrome. Nutrition. 2006 Mar;22(3):334-42. doi: 10.1016/j.nut.2005.10.003. Epub 2006 Jan 18. PMID: 16413751.
  2. Romano C, Comito D, Famiani A, Calamarà S, Loddo I. Partially hydrolyzed guar gum in pediatric functional abdominal pain. World J Gastroenterol. 2013 Jan 14;19(2):235-40. doi: 10.3748/wjg.v19.i2.235. PMID: 23345946; PMCID: PMC3547554.
  3. Parisi GC, Zilli M, Miani MP, Carrara M, Bottona E, Verdianelli G, Battaglia G, Desideri S, Faedo A, Marzolino C, Tonon A, Ermani M, Leandro G. High-fiber diet supplementation in patients with irritable bowel syndrome (IBS): a multicenter, randomized, open trial comparison between wheat bran diet and partially hydrolyzed guar gum (PHGG). Dig Dis Sci. 2002 Aug;47(8):1697-704. doi: 10.1023/a:1016419906546. PMID: 12184518.
  4. Mahendra P. Kapoor, Masaaki Sugita, Yoshitaka Fukuzawa, Tsutomu Okubo, Impact of partially hydrolyzed guar gum (PHGG) on constipation prevention: A systematic review and meta-analysis, Journal of Functional Foods, Volume 33, 2017, Pages 52-66, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2017.03.028.
  5. Elizabeth Steels, Rene Erhardt, Joanna E. Harnett, Vanessa Vigar, Kathryn J. Steadman, Efficacy of a prebiotic formulation for treatment of functional constipation and associated gastrointestinal symptoms in adults: A randomised controlled trial, Advances in Integrative Medicine, Volume 10, Issue 2, 2023, Pages 43-50, ISSN 2212-9588, https://doi.org/10.1016/j.aimed.2023.05.001.
  6. Polymeros D, Beintaris I, Gaglia A, Karamanolis G, Papanikolaou IS, Dimitriadis G, Triantafyllou K. Partially hydrolyzed guar gum accelerates colonic transit time and improves symptoms in adults with chronic constipation. Dig Dis Sci. 2014 Sep;59(9):2207-14. doi: 10.1007/s10620-014-3135-1. Epub 2014 Apr 8. PMID: 24711073.
  7. Inoue R, Sakaue Y, Kawada Y, Tamaki R, Yasukawa Z, Ozeki M, Ueba S, Sawai C, Nonomura K, Tsukahara T, Naito Y. Dietary supplementation with partially hydrolyzed guar gum helps improve constipation and gut dysbiosis symptoms and behavioral irritability in children with autism spectrum disorder. J Clin Biochem Nutr. 2019 May;64(3):217-223. doi: 10.3164/jcbn.18-105. Epub 2019 Mar 7. PMID: 31138955; PMCID: PMC6529696.
  8. Yasukawa Z, Inoue R, Ozeki M, Okubo T, Takagi T, Honda A, Naito Y. Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial. Nutrients. 2019 Sep 10;11(9):2170. doi: 10.3390/nu11092170. PMID: 31509971; PMCID: PMC6769658.
  9. Rosli, D., Shahar, S., Manaf, Z., Lau, H., Yusof, N., Haron, M., & Majid, H. (2020). A Randomised Controlled Trial on the Effect of Partially Hydrolyzed Guar Gum (PHGG) Supplementation on DAiarrhea Frequency and Gut Microbiome Count Among Pelvic Radiation Patients.. JPEN. Journal of parenteral and enteral nutrition. https://doi.org/10.1002/jpen.1987.
  10. Nakamura S, Hongo R, Moji K, Oku T. Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans. Eur J Clin Nutr. 2007 Sep;61(9):1086-93. doi: 10.1038/sj.ejcn.1602623. Epub 2007 Jan 24. PMID: 17251924.
  11. Tsutomu Okubo, Noriyuki Ishihara, Hidehisa Takahashi, Tomohiko Fujisawa, Mujo Kim, Takehiko Yamamoto, Tomotari Mitsuoka, Effects of Partially Hydrolyzed Guar Gum Intake on Human Intestinal Microflora and Its Metabolism, Bioscience, Biotechnology, and Biochemistry, Volume 58, Issue 8, 1 January 1994, Pages 1364–1369, https://doi.org/10.1271/bbb.58.1364
  12. Ohashi Y, Sumitani K, Tokunaga M, Ishihara N, Okubo T, Fujisawa T. Consumption of partially hydrolysed guar gum stimulates Bifidobacteria and butyrate-producing bacteria in the human large intestine. Benef Microbes. 2015;6(4):451-5. doi: 10.3920/BM2014.0118. Epub 2015 Feb 12. PMID: 25519526.
  13. Pylkas AM, Juneja LR, Slavin JL. Comparison of different fibers for in vitro production of short chain fatty acids by intestinal microflora. J Med Food. 2005 Spring;8(1):113-6. doi: 10.1089/jmf.2005.8.113. PMID: 15857221.
  14. Reider SJ, Moosmang S, Tragust J, Trgovec-Greif L, Tragust S, Perschy L, Przysiecki N, Sturm S, Tilg H, Stuppner H, Rattei T, Moschen AR. Prebiotic Effects of Partially Hydrolyzed Guar Gum on the Composition and Function of the Human Microbiota-Results from the PAGODA Trial. Nutrients. 2020 Apr 28;12(5):1257. doi: 10.3390/nu12051257. PMID: 32354152; PMCID: PMC7281958.
  15. Mahendra P. Kapoor, Masaaki Koido, Mikiko Kawaguchi, Derek Timm, Makoto Ozeki, Mari Yamada, Takayuki Mitsuya, Tsutomu Okubo, Lifestyle related changes with partially hydrolyzed guar gum dietary fiber in healthy athlete individuals – A randomized, double-blind, crossover, placebo-controlled gut microbiome clinical study, Journal of Functional Foods, Volume 72, 2020, 104067, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2020.104067.
  16. Wu KL, Rayner CK, Chuah SK, Changchien CS, Lu SN, Chiu YC, Chiu KW, Lee CM. Effects of ginger on gastric emptying and motility in healthy humans. Eur J Gastroenterol Hepatol. 2008 May;20(5):436-40. doi: 10.1097/MEG.0b013e3282f4b224. PMID: 18403946.
  17. Karampour, N., Arzi, A., Rezaie, A., Pashmforoosh, M., & Kordi, F. (2019). Gastroprotective Effect of Zingerone on Ethanol-Induced Gastric Ulcers in Rats. Medicina, 55. https://doi.org/10.3390/medicina55030064.
  18. Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem Toxicol. 2008 Feb;46(2):409-20. doi: 10.1016/j.fct.2007.09.085. Epub 2007 Sep 18. PMID: 17950516
  19. Lashgari, N., Roudsari, N., Khayatan, D., Shayan, M., Momtaz, S., Roufogalis, B., Abdolghaffari, A., & Sahebkar, A. (2021). Ginger and its constituents: Role in treatment of inflammatory bowel disease. BioFactors, 48, 21 – 7. https://doi.org/10.1002/biof.1808.
  20. Terry R, Posadzki P, Watson LK, Ernst E. The use of ginger (Zingiber officinale) for the treatment of pain: a systematic review of clinical trials. Pain Med. 2011 Dec;12(12):1808-18. doi: 10.1111/j.1526-4637.2011.01261.x. Epub 2011 Nov 4. PMID: 22054010.
El producto ha sido añadido a tu carrito Ver carrito →