specialista nella salute dell’apparato digerente dal 2008

specialista nella salute dell’apparato digerente dal 2008

Dal 2008 sviluppiamo e produciamo integratori alimentari. I nostri prodotti sono sviluppati con grande cura e attenzione dai nostri nutrizionisti interni. Per la composizione dei nostri prodotti utilizziamo solo gli ingredienti necessari, quindi i nostri prodotti sono puri, privi di glutine e soia e di alta qualità. Questo garantisce che i nostri integratori possano essere utilizzati in modo sicuro e senza effetti collaterali negativi. I nostri prodotti sono certificati a basso contenuto di FODMAP™ dalla Monash University.

consulenza nutrizionale gratuita

consulenza nutrizionale gratuita

Il nostro team di nutrizionisti specializzati è sempre al tuo servizio con consigli pratici e informazioni aggiuntive sui nostri prodotti. Contattaci via:

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Mail – info@intoleran.com

Telefono – +31302272172

oltre 100.000 clienti soddisfatti

oltre 100.000 clienti soddisfatti

Dal 2008, la nostra missione è quella di aiutare tutti a godersi il cibo. Siamo orgogliosi di aver già aiutato più di 100.000 clienti.

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Background scientifico

Bibliografia

Elenco degli articoli scientifici

  1. Storhaug CL, Fosse SK, Fadnes LT. Country, regional, and global estimates for lactose malabsorption in adults: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2017 Oct;2(10):738-746. doi: 10.1016/S2468-1253(17)30154-1. Epub 2017 Jul 7. PMID: 28690131.
  2. Baijal R, Tandon RK. Effect of lactase on symptoms and hydrogen breath levels in lactose intolerance: A crossover placebo-controlled study. JGH Open. 2020 Dec 1;5(1):143-148. doi: 10.1002/jgh3.12463. PMID: 33490624; PMCID: PMC7812489.
  3. Montalto M, Nucera G, Santoro L, Curigliano V, Vastola M, Covino M, Cuoco L, Manna R, Gasbarrini A, Gasbarrini G. Effect of exogenous beta-galactosidase in patients with lactose malabsorption and intolerance: a crossover double-blind placebo-controlled study. Eur J Clin Nutr. 2005 Apr;59(4):489-93. doi: 10.1038/sj.ejcn.1602098. PMID: 15674309.
  4. Montalto M, Nucera G, Santoro L, Curigliano V, Vastola M, Covino M, Cuoco L, Manna R, Gasbarrini A, Gasbarrini G. Effect of exogenous beta-galactosidase in patients with lactose malabsorption and intolerance: a crossover double-blind placebo-controlled study. Eur J Clin Nutr. 2005 Apr;59(4):489-93. doi: 10.1038/sj.ejcn.1602098. PMID: 15674309.
  5. Kanabar D, Randhawa M, Clayton P. Improvement of symptoms in infant colic following reduction of lactose load with lactase. J Hum Nutr Diet. 2001 Oct;14(5):359-63. doi: 10.1046/j.1365-277x.2001.00304.x. Erratum in: J Hum Nutr Diet. 2007 Oct;20(5):509. PMID: 11906576.
  6. Ahmed M, Billoo AG, Iqbal K, Memon A. Clinical Efficacy Of Lactase Enzyme Supplement In Infant Colic: A Randomised Controlled Trial. J Pak Med Assoc. 2018 Dec;68(12):1744-1747. PMID: 30504935.
  7. Fassio, F.; Facioni, M.S.; Guagnini, F. Lactose Maldigestion, Malabsorption, and Intolerance: A Comprehensive Review with a Focus on Current Management and Future Perspectives. Nutrients 2018, 10, 1599. https://doi.org/10.3390/nu10111599
  8. Leis, R.; de Castro, M.-J.; de Lamas, C.; Picáns, R.; Couce, M.L. Effects of Prebiotic and Probiotic Supplementation on Lactase Deficiency and Lactose Intolerance: A Systematic Review of Controlled Trials. Nutrients 2020, 12, 1487. https://doi.org/10.3390/nu12051487
  9. Oak SJ, Jha R. The effects of probiotics in lactose intolerance: A systematic review. Crit Rev Food Sci Nutr. 2019;59(11):1675-1683. doi: 10.1080/10408398.2018.1425977. Epub 2018 Feb 9. PMID: 29425071.
  10. J, R., AR, G., JM, H., & G, M. (2012). Probiotics and lactose intolerance. In InTech eBooks. https://doi.org/10.5772/51424
  11. C. Pongracz, M. Pfisterer, A. Missbichler, 22 Orally administered xylose isomerase converts fructose to glucose – a promising approach in case of fructose malabsorption, Clinical Nutrition Supplements, Volume 5, Issue 1, 2010, Pages 12-13, ISSN 1744-1161, https://doi.org/10.1016/S1744-1161(10)70022-3. (https://www.sciencedirect.com/science/article/pii/S1744116110700223)
  12. Bhosale SH, Rao MB, Deshpande VV.1996.Molecular and industrial aspects of glucose isomerase. Microbiol Rev60:.https://doi.org/10.1128/mr.60.2.280-300.1996
  13. Di Stefano, M., Miceli, E., Gotti, S. et al. The Effect of Oral α-Galactosidase on Intestinal Gas Production and Gas-Related Symptoms. Dig Dis Sci 52, 78-83 (2007). https://doi.org/10.1007/s10620-006-9296-9
  14. Shepherd, S., & Gibson, P. (2014). The complete Low-FODMAP diet: The revolutionary plan for managing symptoms in IBS, Crohn’s disease, coeliac disease and other digestive disorders. Random House.
  15. Fedewa A, Rao SS. Dietary fructose intolerance, fructan intolerance and FODMAPs.Curr Gastroenterol Rep. 2014 Jan;16(1):370. doi: 10.1007/s11894-013-0370-0. PMID: 24357350; PMCID: PMC3934501.
  16. Böhn L, Törnblom H, Van Oudenhove L, Simrén M, Störsrud S. A randomised double-blind placebo-controlled crossover pilot study: Acute effects of the enzyme α-galactosidase on gastrointestinal symptoms in irritable bowel syndrome patients. Neurogastroenterol Motil. 2021 Jul;33(7):e14094. doi: 10.1111/nmo.14094. Epub 2021 Feb 22. PMID: 33619835.
  17. Ganiats TG, Norcross WA, Halverson AL, Burford PA, Palinkas LA. Does Beano prevent gas? A double-blind crossover study of oral alpha-galactosidase to treat dietary oligosaccharide intolerance. J Fam Pract. 1994 Nov;39(5):441-5. PMID: 7964541.
  18. Di Pierro F, Bertuccioli A, Marini E, Ivaldi L. A pilot trial on subjects with lactose and/or oligosaccharides intolerance treated with a fixed mixture of pure and enteric-coated α- and β-galactosidase. Clin Exp Gastroenterol. 2015 Feb 19;8:95-100. doi: 10.2147/CEG.S79449. PMID: 25733920; PMCID: PMC4340330.
  19. Hillilä, M., Färkkilä, M. A., Sipponen, T., Rajala, J., & Koskenpato, J. (2015). Does oral α-galactosidase relieve irritable bowel symptoms? Scandinavian Journal of Gastroenterology, 51(1), 16-21. https://doi.org/10.3109/00365521.2015.1063156
  20. Di Stefano, M., Miceli, E., Gotti, S. et al. The Effect of Oral α-Galactosidase on Intestinal Gas Production and Gas-Related Symptoms. Dig Dis Sci 52, 78-83 (2007). https://doi.org/10.1007/s10620-006-9296-9
  21. Di Nardo G, Oliva S, Ferrari F, Mallardo S, Barbara G, Cremon C, Aloi M, Cucchiara S. Efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children: a randomised, double-blind, placebo controlled trial. BMC Gastroenterol. 2013 Sep 24;13:142. doi: 10.1186/1471-230X-13-142. PMID: 24063420; PMCID: PMC3849317.
  22. Tuck CJ, Taylor KM, Gibson PR, Barrett JS, Muir JG. Increasing Symptoms in Irritable Bowel Symptoms With Ingestion of Galacto-Oligosaccharides Are Mitigated by α-Galactosidase Treatment. Am J Gastroenterol. 2018 Jan;113(1):124-134. doi: 10.1038/ajg.2017.245. Epub 2017 Aug 15. PMID: 28809383.
  23. Schnedl, W.J., Schenk, M., Lackner, S. et al. Diamine oxidase supplementation improves symptoms in patients with histamine intolerance. Food Sci Biotechnol 28, 1779-1784 (2019). https://doi.org/10.1007/s10068-019-00627-3
  24. Schnedl WJ, Lackner S, Enko D, Schenk M, Holasek SJ, Mangge H. Evaluation of symptoms and symptom combinations in histamine intolerance. Intest Res. 2019 Jul;17(3):427-433. doi: 10.5217/ir.2018.00152. Epub 2019 Mar 7. PMID: 30836736; PMCID: PMC6667364.
  25. Komericki P, Klein G, Reider N, Hawranek T, Strimitzer T, Lang R, Kranzelbinder B, Aberer W. Histamine intolerance: lack of reproducibility of single symptoms by oral provocation with histamine: a randomised, double-blind, placebo-controlled cross-over study. Wien Klin Wochenschr. 2011 Jan;123(1-2):15-20. doi: 10.1007/s00508-010-1506-y. Epub 2010 Dec 20. PMID: 21165702.
  26. Manzotti G, Breda D, Di Gioacchino M, Burastero SE. Serum diamine oxidase activity in patients with histamine intolerance. Int J Immunopathol Pharmacol. 2016 Mar;29(1):105-11. doi: 10.1177/0394632015617170. Epub 2015 Nov 16. PMID: 26574488; PMCID: PMC5806734.
  27. Izquierdo-Casas J, Comas-Basté O, Latorre-Moratalla ML, Lorente-Gascón M, Duelo A, Soler-Singla L, Vidal-Carou MC. Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomised double-blind trial. Clin Nutr. 2019 Feb;38(1):152-158. doi: 10.1016/j.clnu.2018.01.013. Epub 2018 Feb 15. PMID: 29475774.
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  36. Small intestinal glucoamylase deficiency and starch malabsorption: A newly recognised alpha-glucosidase deficiency in children, Lebenthal, Emanuel et al, The Journal of Pediatrics, Volume 124, Issue 4, 541 – 546
  37. Aurigchio, S., Ciccimarra, F., Moauro, L. et al. Intraluminal and Mucosal Starch Digestion in Congenital Deficiency of Intestinal Sucrase and Isomaltase Activities. Pediatr Res 6, 832-839 (1972). https://doi.org/10.1203/00006450-197211000-00004
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